Curr Opin Pharmacol. 2002 Oct;2(5):541-7.

Novel technologies for studying virus-host interaction and discovering new drug targets for HCV and HIV.

Source

Immusol Inc., San Diego, CA 92121, USA. tang@immusol.com

Abstract

A new paradigm for antiviral therapy focuses on targeting cellular genes that are critical for viral replication and pathogenesis. Several new technologies have contributed to the identification of such genes for human immunodeficiency virus and hepatitis C virus. These include proteomic approaches that identify cellular proteins that physically interact with viral proteins, genomic approaches that identify and functionally validate essential cellular co-factor genes, and novel cell biology systems that facilitate studies of virus-host interactions.

PMID:: 12324256; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Hepatitis C - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology. [Hepatology. 2007]
Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology.
Ng TI, Mo H, Pilot-Matias T, He Y, Koev G, Krishnan P, Mondal R, Pithawalla R, He W, Dekhtyar T, et al. Hepatology. 2007 Jun; 45(6):1413-21.
Review [Molecular mechanisms of the hepatitis C virus, potential therapeutic targets]. [Rev Invest Clin. 2003]
Review [Molecular mechanisms of the hepatitis C virus, potential therapeutic targets].
Rivas-Estilla AM, Panduro A. Rev Invest Clin. 2003 Jan-Feb; 55(1):51-64.
Review Structural biology of hepatitis C virus. [Clin Liver Dis. 2003]
Review Structural biology of hepatitis C virus.
Penin F. Clin Liver Dis. 2003 Feb; 7(1):1-21, vii.
Review Host-virus interactions during hepatitis C virus infection: a complex and dynamic molecular biosystem. [Mol Biosyst. 2010]
Review Host-virus interactions during hepatitis C virus infection: a complex and dynamic molecular biosystem.
Pezacki JP, Singaravelu R, Lyn RK. Mol Biosyst. 2010 Jul; 6(7):1131-42.
Review Structural biology of hepatitis C virus. [Hepatology. 2004]
Review Structural biology of hepatitis C virus.
Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM. Hepatology. 2004 Jan; 39(1):5-19.

See reviews... See all...

Cited by 1 PubMed Central article

HIV-1 replication in cell lines harboring INI1/hSNF5 mutations. [Retrovirology. 2006]
HIV-1 replication in cell lines harboring INI1/hSNF5 mutations.
Sorin M, Yung E, Wu X, Kalpana GV. Retrovirology. 2006 Aug 31; 3:56. Epub 2006 Aug 31.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Novel technologies for studying virus-host interaction and discovering new drug ...
Novel technologies for studying virus-host interaction and discovering new drug targets for HCV and HIV.
Curr Opin Pharmacol. 2002 Oct ;2(5):541-7.

PubMed
[Causes of inflammation of an artificial esophagus and its treatment].
[Causes of inflammation of an artificial esophagus and its treatment].
Vestn Khir Im I I Grek. 1975 Sep ;114(9):83-7.

PubMed
HIV integrase as a target for antiviral chemotherapy.
HIV integrase as a target for antiviral chemotherapy.
Rev Med Virol. 2002 May-Jun ;12(3):179-93.

PubMed
Nomenclature of eukaryotic DNA polymerases.
Nomenclature of eukaryotic DNA polymerases.
Science. 1975 Oct 24 ;190(4212):401-2.

PubMed
Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A an...
Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination.
Nucleic Acids Res. 2002 Jan 15 ;30(2):581-91.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: