Malar J. 2002 Feb 8;1:1.

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria.

Fivelman QL, Butcher GA, Adagu IS, Warhurst DC, Pasvol G.

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Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. quinton.fivelman@lshtm.ac.uk

Abstract

We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.

PMID:: 12057021; [PubMed - indexed for MEDLINE]
PMCID: PMC111499

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Chemical compound information

Proguanil

MW: 253.73 g/mol

MF: C₁₁H₁₆ClN₅

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