Trends Parasitol. 2002 May;18(5):224-30.

Combating malaria in Africa.

Trape JF, Pison G, Spiegel A, Enel C, Rogier C.

Source

Institut de Recherche pour le Développement (IRD, formerly ORSTOM), BP 1386, Dakar, Senegal. trape@ird.sn

Abstract

The spread of antimalarial drug resistance has major consequences for malaria control in tropical Africa. Here, the impact of chloroquine resistance on the burden of malaria is analyzed and its implications for the Roll Back Malaria initiative are examined. Malaria mortality has increased at least twofold during the past two decades. Combination therapy should be available for home treatment of young children. The potential toxicity of most antimalarials will require special surveillance programs. The main contribution to malaria control using methods to reduce the entomological inoculation rate is expected in areas with low or unstable transmission. Classic vector-control methods could potentially eliminate malaria in most urban areas and such programs deserve high priority.

PMID:: 11983604; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Review The public health impact of chloroquine resistance in Africa. [Am J Trop Med Hyg. 2001]
Review The public health impact of chloroquine resistance in Africa.
Trape JF. Am J Trop Med Hyg. 2001 Jan-Feb; 64(1-2 Suppl):12-7.
Impact of chloroquine resistance on malaria mortality. [C R Acad Sci III. 1998]
Impact of chloroquine resistance on malaria mortality.
Trape JF, Pison G, Preziosi MP, Enel C, Desgrées du Loû A, Delaunay V, Samb B, Lagarde E, Molez JF, Simondon F. C R Acad Sci III. 1998 Aug; 321(8):689-97.
The mortality consequences of the continued use of chloroquine in Africa: experience in Siaya, western Kenya. [Am J Trop Med Hyg. 2003]
The mortality consequences of the continued use of chloroquine in Africa: experience in Siaya, western Kenya.
Zucker JR, Ruebush TK 2nd, Obonyo C, Otieno J, Campbell CC. Am J Trop Med Hyg. 2003 Apr; 68(4):386-90.
Review Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparum. [Acta Trop. 2005]
Review Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparum.
Barnes KI, White NJ. Acta Trop. 2005 Jun; 94(3):230-40.
"Pseudo-resistant" malaria in tropical countries. [Lancet. 1992]
"Pseudo-resistant" malaria in tropical countries.
Carme B. Lancet. 1992 Oct 10; 340(8824):896-7.

See reviews... See all...

Cited by 26 PubMed Central articles

Hitting hotspots: spatial targeting of malaria for control and elimination. [PLoS Med. 2012]
Hitting hotspots: spatial targeting of malaria for control and elimination.
Bousema T, Griffin JT, Sauerwein RW, Smith DL, Churcher TS, Takken W, Ghani A, Drakeley C, Gosling R. PLoS Med. 2012 Jan; 9(1):e1001165. Epub 2012 Jan 31.
Ethnodiagnostic skills of the digo community for malaria: a lead to traditional bioprospecting. [Front Pharmacol. 2011]
Ethnodiagnostic skills of the digo community for malaria: a lead to traditional bioprospecting.
Nguta JM, Mbaria JM, Gathumbi PK, Gakuya D, Kabasa JD, Kiama SG. Front Pharmacol. 2011; 2:30. Epub 2011 Jun 24.
High frequency of Plasmodium falciparum chloroquine resistance marker (pfcrt T76 mutation) in Yemen: an urgent need to re-examine malaria drug policy. [Parasit Vectors. 2011]
High frequency of Plasmodium falciparum chloroquine resistance marker (pfcrt T76 mutation) in Yemen: an urgent need to re-examine malaria drug policy.
Al-Mekhlafi AM, Mahdy MA, Al-Mekhlafi HM, Azazy AA, Fong MY. Parasit Vectors. 2011 May 27; 4:94. Epub 2011 May 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Combating malaria in Africa.
Combating malaria in Africa.
Trends Parasitol. 2002 May ;18(5):224-30.

PubMed
A single amino acid residue can determine the sensitivity of SERCAs to artemisin...
A single amino acid residue can determine the sensitivity of SERCAs to artemisinins.
Nat Struct Mol Biol. 2005 Jul ;12(7):628-9. Epub 2005 Jun 5 .

PubMed
Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria preve...
Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria prevention and control interventions.
Malar J. 2010 Feb 24 ;9:58.

PubMed
Increased risk for malaria in chronically malnourished children under 5 years of...
Increased risk for malaria in chronically malnourished children under 5 years of age in rural Gambia.
J Trop Pediatr. 2002 Apr ;48(2):78-83.

PubMed
[Erythrocyte defects and parasitemia density in patients with Plasmodium falcipa...
[Erythrocyte defects and parasitemia density in patients with Plasmodium falciparum malaria in Buenaventura, Colombia].
Rev Panam Salud Publica. 2005 Jul ;18(1):25-32.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Combating malaria in Africa.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Related citations

Cited by 26 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information