Genome Biol. 2002;3(4):REVIEWS1008. Epub 2002 Mar 13.

Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope.

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Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. lgerace@scripps.edu

Abstract

Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.

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PMCID: PMC139347

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