Crit Care. 2002 Apr;6(2):102-5. Epub 2002 Feb 8.

Insulin: a wonder drug in the critically ill?

Johan Groeneveld AB, Beishuizen A, Visser FC.

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Department of Intensive Care, Institute of Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. johan.groeneveld@vumc.nl

Abstract

Stress hyperglycaemia is a common event in acute critical illness. There is increasing evidence that maintaining normoglycaemia and treatment with insulin (or with glucose-insulin-potassium [GIK]), even in non-diabetic persons, is helpful in limiting organ damage after myocardial infarction, stroke, traumatic brain injury and other conditions, even though the conditions may be accompanied by insulin resistance. A landmark study now suggests that maintaining normoglycaemia with intensive insulin treatment in a heterogeneous population of critically ill patients decreases morbidity and mortality. The potential mechanisms that underlie such a beneficial effect are discussed.

PMID:: 11983030; [PubMed - indexed for MEDLINE]
PMCID: PMC137286

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