Lancet. 2002 Feb 9;359(9305):497-8.

Merkel cell carcinoma and HIV infection.

Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW.

Abstract

Merkel cell carcinoma (MCC) is a rare skin cancer that occurs more frequently after organ transplantation or B-cell malignancy, conditions of suppressed or disordered immunity. To assess further whether immune suppression increases MCC risk, we studied its occurrence in a cohort of 309365 individuals with acquired immunodeficiency syndrome (AIDS) by using linked AIDS and cancer registries. We identified six cases of MCC, corresponding to a relative risk of 13.4 (95% CI 4.9-29.1) compared with the general population. These results suggest that immune suppression induced by the human immunodeficiency virus increases MCC risk.

PMID:: 11853800; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Merkel cell carcinoma and melanoma: etiological similarities and differences. [Cancer Epidemiol Biomarkers Prev. 1999]
Merkel cell carcinoma and melanoma: etiological similarities and differences.
Miller RW, Rabkin CS. Cancer Epidemiol Biomarkers Prev. 1999 Feb; 8(2):153-8.
Merkel cell carcinoma: changing incidence trends. [J Surg Oncol. 2005]
Merkel cell carcinoma: changing incidence trends.
Hodgson NC. J Surg Oncol. 2005 Jan 1; 89(1):1-4.
Merkel cell carcinoma in a human immunodeficiency virus-infected patient. [Br J Dermatol. 2002]
Merkel cell carcinoma in a human immunodeficiency virus-infected patient.
Calza L, Beltrami C, Manfredi R, Colangeli V, Freo E, Chiodo F. Br J Dermatol. 2002 May; 146(5):895-8.
Review Merkel cell carcinoma. [Cell Mol Life Sci. 2009]
Review Merkel cell carcinoma.
Becker JC, Schrama D, Houben R. Cell Mol Life Sci. 2009 Jan; 66(1):1-8.
Review Fine-needle aspiration diagnosis of unusual cutaneous neoplasms of the scalp in HIV-infected patients: a report of two cases and review of the literature. [Diagn Cytopathol. 2001]
Review Fine-needle aspiration diagnosis of unusual cutaneous neoplasms of the scalp in HIV-infected patients: a report of two cases and review of the literature.
Solomon RK, Lundeen SJ, Hamlar DD, Pambuccian SE. Diagn Cytopathol. 2001 Mar; 24(3):186-92.

See reviews... See all...

Cited by 29 PubMed Central articles

Merkel cell carcinoma of skin-current controversies and recommendations. [Rare Tumors. 2011]
Merkel cell carcinoma of skin-current controversies and recommendations.
Assouline A, Tai P, Joseph K, Lian JD, Krzisch C, Yu E. Rare Tumors. 2011 Apr 4; 3(2):e23.
Merkel cell tumor of the skin treated with localized radiotherapy: are widely negative margins required? [Rare Tumors. 2011]
Merkel cell tumor of the skin treated with localized radiotherapy: are widely negative margins required?
Trombetta M, Packard M, Velosa C, Silverman J, Werts D, Parda D. Rare Tumors. 2011 Mar 30; 3(1):e12. Epub 2011 Mar 30.
Merkel cell polyomavirus in Merkel cell carcinoma of Italian patients. [Virol J. 2011]
Merkel cell polyomavirus in Merkel cell carcinoma of Italian patients.
Paolini F, Donati P, Amantea A, Bucher S, Migliano E, Venuti A. Virol J. 2011 Mar 7; 8:103. Epub 2011 Mar 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Merkel cell carcinoma and HIV infection.
Merkel cell carcinoma and HIV infection.
Lancet. 2002 Feb 9 ;359(9305):497-8.

PubMed
AIDS-associated Kaposi's sarcoma in a heterosexual male--a case report.
AIDS-associated Kaposi's sarcoma in a heterosexual male--a case report.
Dermatol Online J. 2002 Oct ;8(2):19.

PubMed
Elevated risk of lung cancer among people with AIDS.
Elevated risk of lung cancer among people with AIDS.
AIDS. 2007 Jan 11 ;21(2):207-13.

PubMed
Lymphoid neoplasms in HIV-positive individuals in India.
Lymphoid neoplasms in HIV-positive individuals in India.
J Acquir Immune Defic Syndr. 2002 Feb 1 ;29(2):181-3.

PubMed
Fine needle aspiration diagnosis in HIV-related lymphadenopathy in Mangalore, In...
Fine needle aspiration diagnosis in HIV-related lymphadenopathy in Mangalore, India.
Acta Cytol. 2002 Jan-Feb ;46(1):35-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: