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    Curr Biol. 2002 Jan 8;12(1):R21-3.

    EGF receptor signalling: roles of star and rhomboid revealed.

    Source

    Institut für Neuro- und Verhaltensbiologie, Universität Münster, 48149, Münster, Germany.

    Abstract

    Recent studies have clarified how the active form of the Drosophila EGF receptor ligand Spitz is produced: Star chaperones Spitz in the ER and mediates its transport to the Golgi, where the intramembrane serine protease Rhomboid cleaves the Spitz proprotein to initiate secretion.

    PMID:
    11790319
    [PubMed - indexed for MEDLINE]

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