Nucleic Acids Res. 1975 Aug;2(8):1329-43.

m7G5'ppp5'GmptcpUp at the 5' terminus of reovirus messenger RNA.

Abstract

In the presence of S-adenosyl methionine the 5' terminal guanosine residue of in vitro synthesized reovirus mRNA becomes methylated at the 2'-OH position. In addition, 7-methyl guanylic acid is condensed covalently at the 5' terminus resulting in the formation of a 5' to 5' triphosphate bridge. Analysis of the 5' terminal sequence of methylated reovirus mRNA revealed that it has the structure m7G5'ppp5'GmpCpUp.

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PMCID:: PMC344385

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