Curr Opin Struct Biol. 2001 Dec;11(6):746-51.

Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures.

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Howard Hughes Medical Institute and Department of Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA. Istvan@borcim.wustl.edu

Abstract

The committed step in the biosynthesis of isoprenoids is catalyzed by HMG-CoA reductase. Recently determined structures of the distantly related bacterial and mammalian HMG-CoA reductases have revealed two distinct classes of the protein with differently formed active sites and oligomeric states. An appreciation of the remarkable differences in the active site architecture may ultimately lead to the development of novel antibacterial agents.

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Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures.

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