Nat Rev Mol Cell Biol. 2001 Nov;2(11):793-805.

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.

Geiger B, Bershadsky A, Pankov R, Yamada KM.

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Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. benny.geiger@weizmann.ac.il

Abstract

Integrin-mediated cell adhesions provide dynamic, bidirectional links between the extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and morphogenesis, focal adhesions and related structures convey information across the cell membrane, to regulate extracellular-matrix assembly, cell proliferation, differentiation, and death. This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.

PMID:: 11715046; [PubMed - indexed for MEDLINE]

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