Nat Rev Genet. 2001 Nov;2(11):869-78.

The many roles of an RNA editor.

Source

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

Abstract

The availability of complete genome sequences has made it clear that gene number is not the sole determinant of the complexity of the proteome. Additional complexity that is not readily detected by genome analysis is present in the number and types of RNA transcript that can be derived from each locus. Although alternative splicing is a well-recognized method of generating diversity, the more subtle mechanism of RNA editing is less familiar.

PMID:: 11715042; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Evidence for large diversity in the human transcriptome created by Alu RNA editing. [Nucleic Acids Res. 2009]
Evidence for large diversity in the human transcriptome created by Alu RNA editing.
Barak M, Levanon EY, Eisenberg E, Paz N, Rechavi G, Church GM, Mehr R. Nucleic Acids Res. 2009 Nov; 37(20):6905-15. Epub 2009 Sep 8.
Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. [PLoS Biol. 2004]
Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome.
Athanasiadis A, Rich A, Maas S. PLoS Biol. 2004 Dec; 2(12):e391. Epub 2004 Nov 9.
Review Gene regulation through RNA editing. [Discov Med. 2010]
Review Gene regulation through RNA editing.
Maas S. Discov Med. 2010 Nov; 10(54):379-86.
Editing efficiency of a Drosophila gene correlates with a distant splice site selection. [RNA. 2005]
Editing efficiency of a Drosophila gene correlates with a distant splice site selection.
Agrawal R, Stormo GD. RNA. 2005 May; 11(5):563-6.
Review RNA editing in regulating gene expression in the brain. [Biochim Biophys Acta. 2008]
Review RNA editing in regulating gene expression in the brain.
Jepson JE, Reenan RA. Biochim Biophys Acta. 2008 Aug; 1779(8):459-70. Epub 2007 Dec 3.

See reviews... See all...

Cited by 47 PubMed Central articles

IPNV with high and low virulence: host immune responses and viral mutations during infection. [Virol J. 2011]
IPNV with high and low virulence: host immune responses and viral mutations during infection.
Skjesol A, Skjæveland I, Elnæs M, Timmerhaus G, Fredriksen BN, Jørgensen SM, Krasnov A, Jørgensen JB. Virol J. 2011 Aug 10; 8:396. Epub 2011 Aug 10.
Review ADAR proteins: double-stranded RNA and Z-DNA binding domains. [Curr Top Microbiol Immunol. 2012]
Review ADAR proteins: double-stranded RNA and Z-DNA binding domains.
Barraud P, Allain FH. Curr Top Microbiol Immunol. 2012; 353:35-60.
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons. [Nucleic Acids Res. 2011]
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.
Ikeda T, Abd El Galil KH, Tokunaga K, Maeda K, Sata T, Sakaguchi N, Heidmann T, Koito A. Nucleic Acids Res. 2011 Jul; 39(13):5538-54. Epub 2011 Mar 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The many roles of an RNA editor.
The many roles of an RNA editor.
Nat Rev Genet. 2001 Nov ;2(11):869-78.

PubMed
The Fusarium graminearum genome reveals a link between localized polymorphism an...
The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.
Science. 2007 Sep 7 ;317(5843):1400-2.

PubMed
Review of proteomics with applications to genetic epidemiology.
Review of proteomics with applications to genetic epidemiology.
Genet Epidemiol. 2003 Feb ;24(2):83-98.

PubMed
Gene ontology analysis for RNA-seq: accounting for selection bias.
Gene ontology analysis for RNA-seq: accounting for selection bias.
Genome Biol. 2010 ;11(2):R14. Epub 2010 Feb 4 .

PubMed
Transport of dsRNA into cells by the transmembrane protein SID-1.
Transport of dsRNA into cells by the transmembrane protein SID-1.
Science. 2003 Sep 12 ;301(5639):1545-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: