Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10505-8. Epub 2001 Aug 27.

A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.

Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T.

Source

Howard Hughes Medical Institute, Genetics Division, Children's Hospital, and Harvard Medical School, Boston, MA 02215, USA. apuca@rascal.med.harvard.edu

Abstract

Substantial evidence supports the familial aggregation of exceptional longevity. The existence of rare families demonstrating clustering for this phenotype suggests that a genetic etiology may be an important component. Previous attempts at localizing loci predisposing for exceptional longevity have been limited to association studies of candidate gene polymorphisms. In this study, a genome-wide scan for such predisposing loci was conducted by using 308 individuals belonging to 137 sibships demonstrating exceptional longevity. By using nonparametric analysis, significant evidence for linkage was noted for chromosome 4 at D4S1564 with a MLS of 3.65 (P = 0.044). The analysis was corroborated by a parametric analysis (P = 0.052). These linkage results indicate the likelihood that there exists a gene, or genes, that exerts a substantial influence on the ability to achieve exceptional old age. Identification of the genes in humans that allow certain individuals to live to extreme old age should lead to insights on cellular pathways that are important to the aging process.

PMID:: 11526246; [PubMed - indexed for MEDLINE]
PMCID: PMC56990

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

chromosome 4 - Genetics Home Reference

Libraries

LinkOut Holdings

Supplemental Content

Related citations

High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. [PLoS One. 2010]
High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci.
Boyden SE, Kunkel LM. PLoS One. 2010 Aug 31; 5(8):e12432. Epub 2010 Aug 31.
Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. [Hypertension. 2001]
Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p.
Allayee H, de Bruin TW, Michelle Dominguez K, Cheng LS, Ipp E, Cantor RM, Krass KL, Keulen ET, Aouizerat BE, Lusis AJ, et al. Hypertension. 2001 Oct; 38(4):773-8.
Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging. [J Gerontol A Biol Sci Med Sci. 2004]
Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging.
Reed T, Dick DM, Uniacke SK, Foroud T, Nichols WC. J Gerontol A Biol Sci Med Sci. 2004 Mar; 59(3):227-32.
Review The genetics of aging. [Curr Opin Genet Dev. 2002]
Review The genetics of aging.
Perls T, Kunkel L, Puca A. Curr Opin Genet Dev. 2002 Jun; 12(3):362-9.
Review Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). [Ann N Y Acad Sci. 2007]
Review Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging).
Franceschi C, Bezrukov V, Blanché H, Bolund L, Christensen K, de Benedictis G, Deiana L, Gonos E, Hervonen A, Yang H, et al. Ann N Y Acad Sci. 2007 Apr; 1100:21-45.

See reviews... See all...

Cited by 34 PubMed Central articles

Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. [Age (Dordr). 2006]
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study.
Willcox DC, Willcox BJ, Hsueh WC, Suzuki M. Age (Dordr). 2006 Dec; 28(4):313-32. Epub 2006 Dec 8.
Centenarian studies: important contributors to our understanding of the aging process and longevity. [Curr Gerontol Geriatr Res. 2010]
Centenarian studies: important contributors to our understanding of the aging process and longevity.
Willcox DC, Willcox BJ, Poon LW. Curr Gerontol Geriatr Res. 2010; 2010:484529. Epub 2011 Jul 13.
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. [Aging Cell. 2011]
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, et al. Aging Cell. 2011 Aug; 10(4):686-98. Epub 2011 May 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniSTS
Genetic, physical, and sequence mapping reagents in the UniSTS database associated with the current articles through references on sequence tagged site (STS) submissions as well as automated searching of PubMed abstracts and full-text PubMed Central articles for marker names.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A genome-wide scan for linkage to human exceptional longevity identifies a locus...
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.
Proc Natl Acad Sci U S A. 2001 Aug 28 ;98(18):10505-8. Epub 2001 Aug 27 .

PubMed
Novel gene conversion between X-Y homologues located in the nonrecombining regio...
Novel gene conversion between X-Y homologues located in the nonrecombining region of the Y chromosome in Felidae (Mammalia).
Proc Natl Acad Sci U S A. 2000 May 9 ;97(10):5307-12.

PubMed
RegulonDB (version 3.2): transcriptional regulation and operon organization in E...
RegulonDB (version 3.2): transcriptional regulation and operon organization in Escherichia coli K-12.
Nucleic Acids Res. 2001 Jan 1 ;29(1):72-4.

PubMed
Deciding among green plants for whole genome studies.
Deciding among green plants for whole genome studies.
Trends Plant Sci. 2002 Dec ;7(12):550-4.

PubMed
Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Revers...
Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.
Plant Cell. 1990 Apr ;2(4):279-289.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: