Science. 2001 Aug 24;293(5534):1503-6.

Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.

Source

Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892-4034, USA.

Abstract

The quiescent nature of most peripheral T cells poses an effective limitation to human immunodeficiency virus (HIV) replication and, in particular, to viral integration into the host chromatin. Two HIV proteins, Nef and Tat, increase T cell activity, but a requirement of integration for viral gene expression would preclude a role for these proteins in resting cells. Here, we report that HIV infection leads to selective transcription of the nef and tat genes before integration. This preintegration transcription in quiescent cells leads to increased T cell activation and viral replication.

PMID:: 11520990; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction. [J Biol Chem. 2004]
Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction.
Fortin JF, Barat C, Beauséjour Y, Barbeau B, Tremblay MJ. J Biol Chem. 2004 Sep 17; 279(38):39520-31. Epub 2004 Jul 16.
Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA. [J Virol. 2007]
Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA.
Poon B, Chang MA, Chen IS. J Virol. 2007 Oct; 81(19):10515-23. Epub 2007 Jul 25.
HIV pathogenesis and activation of CD4 cells. [AIDS Clin Care. 2001]
HIV pathogenesis and activation of CD4 cells.
Albrecht H. AIDS Clin Care. 2001 Oct; 13(10):99.
Review Role of viral regulatory and accessory proteins in HIV-1 replication. [Front Biosci. 2004]
Review Role of viral regulatory and accessory proteins in HIV-1 replication.
Seelamgari A, Maddukuri A, Berro R, de la Fuente C, Kehn K, Deng L, Dadgar S, Bottazzi ME, Ghedin E, Pumfery A, et al. Front Biosci. 2004 Sep 1; 9:2388-413. Epub 2004 Sep 1.
Review Inhibitors of HIV-1 gene expression and transcription. [Curr Top Med Chem. 2004]
Review Inhibitors of HIV-1 gene expression and transcription.
Baba M. Curr Top Med Chem. 2004; 4(9):871-82.

See reviews... See all...

Cited by 85 PubMed Central articles

A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs. [PLoS One. 2012]
A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs.
Lassen KG, Hebbeler AM, Bhattacharyya D, Lobritz MA, Greene WC. PLoS One. 2012; 7(1):e30176. Epub 2012 Jan 24.
The inside out of lentiviral vectors. [Viruses. 2011]
The inside out of lentiviral vectors.
Durand S, Cimarelli A. Viruses. 2011 Feb; 3(2):132-59. Epub 2011 Feb 14.
Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2. [Retrovirology. 2011]
Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2.
Olivieri KC, Mukerji J, Gabuzda D. Retrovirology. 2011 Aug 5; 8:64. Epub 2011 Aug 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Selective transcription and modulation of resting T cell activity by preintegrat...
Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.
Science. 2001 Aug 24 ;293(5534):1503-6.

PubMed
Growth-rate recovery of Escherichia coli cultures carrying a multicopy plasmid, ...
Growth-rate recovery of Escherichia coli cultures carrying a multicopy plasmid, by engineering of the pentose-phosphate pathway.
Biotechnol Bioeng. 2004 Aug 20 ;87(4):485-94.

PubMed
Genetic Contributions to Understanding Polyketide Synthases.
Genetic Contributions to Understanding Polyketide Synthases.
Chem Rev. 1997 Nov 10 ;97(7):2465-2498.

PubMed
The importance of intrinsic disorder for protein phosphorylation.
The importance of intrinsic disorder for protein phosphorylation.
Nucleic Acids Res. 2004 Feb 11 ;32(3):1037-49. Print 2004 .

PubMed
Evolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes re...
Evolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes reveals plastid phylogeny and thousands of cyanobacterial genes in the nucleus.
Proc Natl Acad Sci U S A. 2002 Sep 17 ;99(19):12246-51. Epub 2002 Sep 6 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Libraries

Supplemental Content

Related citations

Cited by 85 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information