Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9.

Lipid rafts and signal transduction.

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Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D-01307 Dresden, Germany. Simons@EMBL-Heidelberg.de

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Nat Rev Mol Cell Biol 2001 Mar;2(3):216.

Abstract

Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface -- known as lipid rafts -- also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades.

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