Trends Biotechnol. 2001 Jun;19(6):205-10.

Whole-cell simulation: a grand challenge of the 21st century.

Source

Institute for Advanced Biosciences, Keio University, 5322 Endo, Fujisawa, 252-8520, Japan. mt@sfc.keio.ac.jp

Abstract

Study of the cell will never be complete unless its dynamic behavior is understood. The complex behavior of the cell cannot be determined or predicted unless a computer model of the cell is constructed and computer simulation is undertaken. Rapid accumulation of biological data from genome, proteome, transcriptome and metabolome projects can bring us to the point where it is no longer purely speculative to discuss how to construct virtual cells in silico. This article describes attempts to construct whole cell models. The E-CELL project has completed a couple of virtual cell models, and computer simulations have revealed some biological surprises.

PMID:: 11356281; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review Search for organising principles: understanding in systems biology. [Syst Biol (Stevenage). 2004]
Review Search for organising principles: understanding in systems biology.
Mesarovic MD, Sreenath SN, Keene JD. Syst Biol (Stevenage). 2004 Jun; 1(1):19-27.
Editorial: computational modelling of cell & tissue processes & function. [J Mol Histol. 2004]
Editorial: computational modelling of cell & tissue processes & function.
Moore MN, Noble D. J Mol Histol. 2004 Sep; 35(7):655-8.
Calculation of surface area and volume of human erythrocytes from scanning electron micrographs. [J Microsc. 1978]
Calculation of surface area and volume of human erythrocytes from scanning electron micrographs.
Leblond PF, Shoucri R. J Microsc. 1978 Jul; 113(2):161-70.
Towards building the silicon cell: a modular approach. [Biosystems. 2006]
Towards building the silicon cell: a modular approach.
Snoep JL, Bruggeman F, Olivier BG, Westerhoff HV. Biosystems. 2006 Feb-Mar; 83(2-3):207-16. Epub 2005 Oct 19.
Review Cytoview: development of a cell modelling framework. [J Biosci. 2007]
Review Cytoview: development of a cell modelling framework.
Khodade P, Malhotra S, Kumar N, Iyengar MS, Balakrishnan N, Chandra N. J Biosci. 2007 Aug; 32(5):965-77.

See reviews... See all...

Cited by 16 PubMed Central articles

A metabolic model of human erythrocytes: practical application of the E-Cell Simulation Environment. [J Biomed Biotechnol. 2010]
A metabolic model of human erythrocytes: practical application of the E-Cell Simulation Environment.
Yachie-Kinoshita A, Nishino T, Shimo H, Suematsu M, Tomita M. J Biomed Biotechnol. 2010; 2010:642420. Epub 2010 Jun 28.
Rule-based spatial modeling with diffusing, geometrically constrained molecules. [BMC Bioinformatics. 2010]
Rule-based spatial modeling with diffusing, geometrically constrained molecules.
Gruenert G, Ibrahim B, Lenser T, Lohel M, Hinze T, Dittrich P. BMC Bioinformatics. 2010 Jun 7; 11:307. Epub 2010 Jun 7.
The Simbios National Center: Systems Biology in Motion. [Proc IEEE Inst Electr Electron...]
The Simbios National Center: Systems Biology in Motion.
Schmidt JP, Delp SL, Sherman MA, Taylor CA, Pande VS, Altman RB. Proc IEEE Inst Electr Electron Eng. 2008 Aug 1; 96(8):1266.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Whole-cell simulation: a grand challenge of the 21st century.
Whole-cell simulation: a grand challenge of the 21st century.
Trends Biotechnol. 2001 Jun ;19(6):205-10.

PubMed
The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, ...
The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa.
J Med Entomol. 1979 May 22 ;15(4):307-417.

PubMed
Cadmium-induced cell transformation and tumorigenesis are associated with transc...
Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species.
Toxicol Sci. 2001 Jun ;61(2):295-303.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: