Trends Parasitol. 2001 May;17(5):236-42.

Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models.

Carlton JM, Hayton K, Cravo PV, Walliker D.

Source

National Center for Biotechnology Research, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA. carlton@nebi.nlm.nih.gov

Abstract

It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.

PMID:: 11323308; [PubMed - indexed for MEDLINE]

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