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    Science. 2001 Apr 6;292(5514):104-6.

    Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

    Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L.

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    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.

    Abstract

    The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

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    PMID:
    11292874
    [PubMed - indexed for MEDLINE]

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