J Mol Evol. 2000 Nov;51(5):459-63.

Replication orientation affects the rate and direction of bacterial gene evolution.

Source

Department of Molecular and Medical Genetics, University of Toronto, 1 King's College Circle, Toronto, Canada, M5S 1A8. e.tillier@utoronto.ca

Abstract

In many bacterial genomes, the leading and lagging strands have different skews in base composition; for example, an excess of guanosine compared to cytosine on the leading strand. We find that Chlamydia genes that have switched their orientation relative to the direction of replication, for example by inversion, acquire the skew of their new "host" strand. In contrast to most evolutionary processes, which have unpredictable effects on the sequence of a gene, replication-related skews reflect a directional evolutionary force that causes predictable changes in the base composition of switched genes, resulting in increased DNA and amino acid sequence divergence.

PMID:: 11080368; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

DNA, Bacterial

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

The differential killing of genes by inversions in prokaryotic genomes. [J Mol Evol. 2001]
The differential killing of genes by inversions in prokaryotic genomes.
Mackiewicz P, Mackiewicz D, Gierlik A, Kowalczuk M, Nowicka A, Dudkiewicz M, Dudek MR, Cebrat S. J Mol Evol. 2001 Dec; 53(6):615-21.
Ongoing evolution of strand composition in bacterial genomes. [Mol Biol Evol. 2001]
Ongoing evolution of strand composition in bacterial genomes.
Rocha EP, Danchin A. Mol Biol Evol. 2001 Sep; 18(9):1789-99.
Base composition skews, replication orientation, and gene orientation in 12 prokaryote genomes. [J Mol Evol. 1998]
Base composition skews, replication orientation, and gene orientation in 12 prokaryote genomes.
McLean MJ, Wolfe KH, Devine KM. J Mol Evol. 1998 Dec; 47(6):691-6.
Review Is there a role for replication fork asymmetry in the distribution of genes in bacterial genomes? [Trends Microbiol. 2002]
Review Is there a role for replication fork asymmetry in the distribution of genes in bacterial genomes?
Rocha E. Trends Microbiol. 2002 Sep; 10(9):393-5.
Review The replication-related organization of bacterial genomes. [Microbiology. 2004]
Review The replication-related organization of bacterial genomes.
Rocha EP. Microbiology. 2004 Jun; 150(Pt 6):1609-27.

See reviews... See all...

Cited by 8 PubMed Central articles

Purifying selection, sequence composition, and context-specific indel mutations shape intraspecific variation in a bacterial endosymbiont. [Genome Biol Evol. 2012]
Purifying selection, sequence composition, and context-specific indel mutations shape intraspecific variation in a bacterial endosymbiont.
Williams LE, Wernegreen JJ. Genome Biol Evol. 2012 Jan; 4(1):44-51. Epub 2011 Nov 24.
New implications on genomic adaptation derived from the Helicobacter pylori genome comparison. [PLoS One. 2011]
New implications on genomic adaptation derived from the Helicobacter pylori genome comparison.
Lara-Ramírez EE, Segura-Cabrera A, Guo X, Yu G, García-Pérez CA, Rodríguez-Pérez MA. PLoS One. 2011 Feb 28; 6(2):e17300. Epub 2011 Feb 28.
Evolutionary rates and gene dispensability associate with replication timing in the archaeon Sulfolobus islandicus. [Genome Biol Evol. 2010]
Evolutionary rates and gene dispensability associate with replication timing in the archaeon Sulfolobus islandicus.
Flynn KM, Vohr SH, Hatcher PJ, Cooper VS. Genome Biol Evol. 2010; 2:859-69. Epub 2010 Oct 26.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Replication orientation affects the rate and direction of bacterial gene evoluti...
Replication orientation affects the rate and direction of bacterial gene evolution.
J Mol Evol. 2000 Nov ;51(5):459-63.

PubMed
Detection and discrimination of orthopoxviruses using microarrays of immobilized...
Detection and discrimination of orthopoxviruses using microarrays of immobilized oligonucleotides.
J Virol Methods. 2003 Sep ;112(1-2):67-78.

PubMed
Sequencing and comparison of yeast species to identify genes and regulatory elem...
Sequencing and comparison of yeast species to identify genes and regulatory elements.
Nature. 2003 May 15 ;423(6937):241-54.

PubMed
Evolutionary analyses of the human genome.
Evolutionary analyses of the human genome.
Nature. 2001 Feb 15 ;409(6822):847-9.

PubMed
Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5.
Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5.
Nat Biotechnol. 2005 Jul ;23(7):873-8. Epub 2005 Jun 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: