Science. 1975 Nov 21;190(4216):784-5.

Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells.

Abstract

Capacity to resorb bone and calcified cartilage was restored permanently in mice with inherited osteopetrosis by the intravenous administration of cell suspensions prepared from spleen and bone marrow of normal littermates. Beginning near active growth plates as early as 2 weeks after transplantation, replacement of the abnormal spongiosa continued until medullary cavitites were fully expanded.

PMID:: 1105786; [PubMed - indexed for MEDLINE]

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Control of bone resorption by hematopoietic tissue. The induction and reversal of congenital osteopetrosis in mice through use of bone marrow and splenic transplants. [J Exp Med. 1975]
Control of bone resorption by hematopoietic tissue. The induction and reversal of congenital osteopetrosis in mice through use of bone marrow and splenic transplants.
Walker DG. J Exp Med. 1975 Sep 1; 142(3):651-63.
Spleen cells transmit osteopetrosis in mice. [Science. 1975]
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Walker DG. Science. 1975 Nov 21; 190(4216):785-7.
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Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells.

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