J Pharm Biomed Anal. 2000 Aug 15;23(2-3):469-75.

High performance liquid chromatographic determination of ambroxol in the presence of different preservatives in pharmaceutical formulations.

Koundourellis JE, Malliou ET, Broussali TA.

Source

Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotelian University, Thessaloniki, Greece. koundour@pharm.auth.gr

Abstract

A high-performance chromatographic method is described for simultaneous determination of ambroxol in the presence of different preservatives in syrups. The method separates ambroxol from methyl- ethyl-, propyl- and butyl paraben and from other multi-component mixtures. The retention behaviour of ambroxol and parabens as a function of both pH and mobile phase composition was investigated. The eluents were monitored with a UV detector at 247 nm. Linear relationships between the amount of pharmaceutical compounds and peak heights were confirmed at the concentrations of 0.74-14.08 microg ml(-1). The high recovery (no extraction of the samples is required) and the low %RSD confirm the suitability of the proposed method for the determination of ambroxol in different pharmaceutical preparations.

PMID:: 10933540; [PubMed - indexed for MEDLINE]

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Cited by 5 PubMed Central articles

A Rapid, Stability Indicating RP-UPLC Method for Simultaneous Determination of Ambroxol Hydrochloride, Cetirizine Hydrochloride and Antimicrobial Preservatives in Liquid Pharmaceutical Formulation. [Sci Pharm. 2011]
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Chemical compound information

Ambroxol

MW: 378.10 g/mol

MF: C₁₃H₁₈Br₂N₂O

See 4 citations for this compound....

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High performance liquid chromatographic determination of ambroxol in the presence of different preservatives in pharmaceutical formulations.

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