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    Proc Natl Acad Sci U S A. 1975 Apr;72(4):1354-8.

    Proposal concerning mechanism of evolution of the genome of Escherichia coli.

    Abstract

    Many pairs of genes whose gene products are functionally related lie either 90 degrees or 180 degrees apart on the circular map of the E. coli chromosome. A mechanism of evolution is proposed that involves two sequential duplications of an ancestral genome, followed by mutation and divergence of function of replicate genes.

    PMID:
    1093179
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC432532
    Free PMC Article

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