J Parasitol. 1975 Feb;61(1):43-50.

Development of infectivity by the Plasmodium berghei sporozoite.

Abstract

Studies were done on the development of infectivity during ontogeny of the sporozoite of the rodent malaria parasite, Plasmodium berghei. Populations of sporozoites were separated from the oocysts, the hemocoel, and the salivary glands, with special precautions being taken to avoid cross-contamination between the different populations. The results indicated that populations of salivary gland sporozoites were more than 10,000 times as infective as populations of oocyst sporozoites from the same mosquitoes. The development of this infectivity appears to be asynchronous, in some cases taking place in the hemocoel, while in other cases not occurring until after the sporozoites have invaded the salivary glands. Thus, the development of infectivity seems to be time-dependent rather than site-dependent. There is also a continued increase in sporozoite infectivity during their residence in the salivary gland. The development of infectivity may be associated with other aspects of sporozoite maturation, including changes in their antigenicity and motility.

PMID:: 1090717; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity. [PLoS Pathog. 2008]
Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity.
Lasonder E, Janse CJ, van Gemert GJ, Mair GR, Vermunt AM, Douradinha BG, van Noort V, Huynen MA, Luty AJ, Kroeze H, et al. PLoS Pathog. 2008 Oct; 4(10):e1000195. Epub 2008 Oct 31.
The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites. [Mol Biochem Parasitol. 2004]
The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites.
Myung JM, Marshall P, Sinnis P. Mol Biochem Parasitol. 2004 Jan; 133(1):53-9.
Disruption of Plasmodium sporozoite transmission by depletion of sporozoite invasion-associated protein 1. [Eukaryot Cell. 2009]
Disruption of Plasmodium sporozoite transmission by depletion of sporozoite invasion-associated protein 1.
Engelmann S, Silvie O, Matuschewski K. Eukaryot Cell. 2009 Apr; 8(4):640-8. Epub 2009 Jan 30.
Population dynamics of sporogony for Plasmodium vivax parasites from western Thailand developing within three species of colonized Anopheles mosquitoes. [Malar J. 2006]
Population dynamics of sporogony for Plasmodium vivax parasites from western Thailand developing within three species of colonized Anopheles mosquitoes.
Zollner GE, Ponsa N, Garman GW, Poudel S, Bell JA, Sattabongkot J, Coleman RE, Vaughan JA. Malar J. 2006 Aug 3; 5:68. Epub 2006 Aug 3.
Review Getting infectious: formation and maturation of Plasmodium sporozoites in the Anopheles vector. [Cell Microbiol. 2006]
Review Getting infectious: formation and maturation of Plasmodium sporozoites in the Anopheles vector.
Matuschewski K. Cell Microbiol. 2006 Oct; 8(10):1547-56.

See reviews... See all...

Cited by 25 PubMed Central articles

Roles of the amino terminal region and repeat region of the Plasmodium berghei circumsporozoite protein in parasite infectivity. [PLoS One. 2012]
Roles of the amino terminal region and repeat region of the Plasmodium berghei circumsporozoite protein in parasite infectivity.
Aldrich C, Magini A, Emiliani C, Dottorini T, Bistoni F, Crisanti A, Spaccapelo R. PLoS One. 2012; 7(2):e32524. Epub 2012 Feb 29.
Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites. [Mol Microbiol. 2011]
Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites.
Haussig JM, Matuschewski K, Kooij TW. Mol Microbiol. 2011 Sep; 81(6):1511-25. Epub 2011 Aug 17.
Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host. [Malar J. 2011]
Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host.
Douradinha B, Augustijn KD, Moore SG, Ramesar J, Mota MM, Waters AP, Janse CJ, Thompson J. Malar J. 2011 Mar 31; 10:71. Epub 2011 Mar 31.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Development of infectivity by the Plasmodium berghei sporozoite.
Development of infectivity by the Plasmodium berghei sporozoite.
J Parasitol. 1975 Feb ;61(1):43-50.

PubMed
Sustainability, affordability, and equity of corporate drug donations: the case ...
Sustainability, affordability, and equity of corporate drug donations: the case of Malarone.
Lancet. 2000 May 13 ;355(9216):1718-20.

PubMed
Observations on the swarming and mating behavior of Anopheles culicifacies Giles...
Observations on the swarming and mating behavior of Anopheles culicifacies Giles in nature.
Bull World Health Organ. 1976 ;54(2):155-8.

PubMed
Interferon gamma eliminates responding CD4 T cells during mycobacterial infectio...
Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells.
J Exp Med. 2000 Jul 3 ;192(1):117-22.

PubMed
Population replacement in Culex fatigans by means of cytoplasmic incompatibility...
Population replacement in Culex fatigans by means of cytoplasmic incompatibility. 2. Field cage experiments with overlapping generations.
Bull World Health Organ. 1976 ;53(1):107-19.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: