Curr Opin Struct Biol. 2000 Jun;10(3):366-70.

Exploitation of gene context.

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European Molecular Biology Laboratory, Max-Delbrück-Centrum for Molecular Medicine, Heidelberg, Berlin-Buch, 69117, 13122, Germany. huynen@embl-heidelberg.de

Abstract

Recently, a number of techniques have been proposed that use completely sequenced genomes for the function prediction of individual proteins encoded therein. They use the fusion of genes, their conserved location in operons or merely their co-occurrence in genomes to predict the existence of functional interactions between the proteins they encode. This type of information complements functional features that are predicted by classical homology-based search techniques.

PMID:: 10851194; [PubMed - indexed for MEDLINE]

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