Arthritis Rheum. 1976 May-Jun;19(3):509-15.

Altered lymphocyte reactivity in rheumatoid arthritis.

Silverman HA, Johnson JS, Vaughan JH, McGlamory JC.

Abstract

Blastogenic transformation of peripheral lymphocytes with phytohemagglutinin (PHA), conconavalin A (Con A), and pokeweed mitogen (PWM) was studied in 29 patients with rheumatoid arthritis (RA). The PHA response was depressed in a subgroup of RA patients with erosive disease. The Con A response was also depressed and paralleled the PHA response. The PWM response was not depressed. These results lend support to the hypothesis of a functional defect of cellular immunity in RA. It was shown that lymphocyte responsiveness to a single mitogen concentration is not an adequate assessment of the overall responsiveness of the lymphocytes tested.

PMID:: 1084749; [PubMed - indexed for MEDLINE]

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