Neuroreport. 2000 Jan 17;11(1):163-6.

Histamine H3-receptor activation inhibits dopamine synthesis in rat striatum.

Molina-Hernández A, Nuñez A, Arias-Montaño JA.

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Departamento de Fisiología, Biofisica y Neurociencias, Centro de Investigación y de Estudios Avanzados, México DF, México.

Abstract

Unilateral 6-hydroxydopamine lesion to rat substantia nigra pars compacta resulted in a modest, but significant, decrease in the specific binding of N-alpha-[methyl-3H]histamine (19 +/- 5% reduction) to synaptosomal membranes from ipsilateral striata. Dopamine synthesis was assessed in striatal slices by determining [3H]DOPA accumulation after inhibition of DOPA decarboxylase. [3H]DOPA synthesis induced by 50 mM K+ (151 +/- 4% of basal) was prevented by either Ca2+ removal or by Ni2+. Depolarization-stimulated [3H]DOPA accumulation was reduced by the selective H3-agonist immepip (100 nM; 68 +/- 7% inhibition). The effect of immepip was reversed by thioperamide (100 nM), a selective H3-antagonist. Taken together, our results indicate that histamine modulates striatal dopamine synthesis by acting at H3-receptors located on dopaminergic nerve terminals.

PMID:: 10683850; [PubMed - indexed for MEDLINE]

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