Curr Opin Immunol. 1999 Dec;11(6):701-7.

Genetic dissection of systemic lupus erythematosus.

Wakeland EK, Wandstrat AE, Liu K, Morel L.

Source

Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235-9093, USA. edward.wakeland@email.swmed.edu

Abstract

Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.

PMID:: 10631557; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Review Genetics and systemic lupus erythematosus. [Curr Rheumatol Rep. 2001]
Review Genetics and systemic lupus erythematosus.
Tsao BP, Grossman JM. Curr Rheumatol Rep. 2001 Jun; 3(3):183-90.
Review Delineating the genetic basis of systemic lupus erythematosus. [Immunity. 2001]
Review Delineating the genetic basis of systemic lupus erythematosus.
Wakeland EK, Liu K, Graham RR, Behrens TW. Immunity. 2001 Sep; 15(3):397-408.
Review Genetics of systemic autoimmunity in mouse models of lupus. [Int Rev Immunol. 2000]
Review Genetics of systemic autoimmunity in mouse models of lupus.
Kono DH, Theofilopoulos AN. Int Rev Immunol. 2000; 19(4-5):367-87.
Review Genetic basis of systemic lupus erythematosus. [Drugs Today (Barc). 2002]
Review Genetic basis of systemic lupus erythematosus.
Hirose S, Jiang Y, Hamano Y, Nishimura H. Drugs Today (Barc). 2002 Mar; 38(3):167-84.
Review An update on genetic studies of systemic lupus erythematosus. [Curr Rheumatol Rep. 2002]
Review An update on genetic studies of systemic lupus erythematosus.
Tsao BP. Curr Rheumatol Rep. 2002 Aug; 4(4):359-67.

See reviews... See all...

Cited by 21 PubMed Central articles

Long-term treatment of NZB mice with anti-CD4 results in wasting disease, lymphoid atrophy and chronic diarrhea. [Gut Microbes. 2010]
Long-term treatment of NZB mice with anti-CD4 results in wasting disease, lymphoid atrophy and chronic diarrhea.
Oliveira GG, Holton J, Lydyard PM. Gut Microbes. 2010 Sep; 1(5):345-355. Epub 2010 May 24.
An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation. [J Immunol. 2010]
An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation.
Tchepeleva SN, Thurman JM, Ruff K, Perkins SJ, Morel L, Boackle SA. J Immunol. 2010 Aug 15; 185(4):2331-9. Epub 2010 Jul 21.
Identification of gp96 as a novel target for treatment of autoimmune disease in mice. [PLoS One. 2010]
Identification of gp96 as a novel target for treatment of autoimmune disease in mice.
Han JM, Kwon NH, Lee JY, Jeong SJ, Jung HJ, Kim HR, Li Z, Kim S. PLoS One. 2010 Mar 23; 5(3):e9792. Epub 2010 Mar 23.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genetic dissection of systemic lupus erythematosus.
Genetic dissection of systemic lupus erythematosus.
Curr Opin Immunol. 1999 Dec ;11(6):701-7.

PubMed
MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocyte...
MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis.
Arthritis Res Ther. 2006 ;8(6):R170.

PubMed
A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas.
A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas.
Gastroenterology. 2006 Dec ;131(6):1674-82. Epub 2006 Sep 1 .

PubMed
Major histocompatibility complex class I-recognizing receptors are disease risk ...
Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis.
J Exp Med. 2001 May 21 ;193(10):1159-67.

PubMed
Biology and therapy of fibromyalgia. Stress, the stress response system, and fib...
Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia.
Arthritis Res Ther. 2007 ;9(4):216.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Genetic dissection of systemic lupus erythematosus.

Source

Abstract

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous

Libraries

Supplemental Content

Related citations

Cited by 21 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information