Proc Natl Acad Sci U S A. 1975 Nov;72(11):4541-5.

Effect of temporal fluctuation of selection coefficient on gene frequency in a population.

Abstract

The diffusion equations describing the change of gene frequencies are extended to indlude the effect of temporal fluctuation of selection coefficient that may persist for some generations. The equilibrium distribution of gene frequencies and the fixation probability of a mutant gene are obtained from the extended equations. Comparison is made with the experimental data on protein polymorphism. A possible bearing of the fluctuation of selection coefficient on the problem of molecular evolution is discussed in relation to the neutral theory.

PMID:: 1060137; [PubMed - indexed for MEDLINE]
PMCID:: PMC388758

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

Proteins

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms. [Genetics. 1973]
Distribution of gene frequency as a test of the theory of the selective neutrality of polymorphisms.
Lewontin RC, Krakauer J. Genetics. 1973 May; 74(1):175-95.
Evolution of a finite population under gene conversion. [Proc Natl Acad Sci U S A. 1983]
Evolution of a finite population under gene conversion.
Nagylaki T. Proc Natl Acad Sci U S A. 1983 Oct; 80(20):6278-81.
Genetic variation in a heterogeneous environment. I. Temporal heterogeneity and the absolute dominance model. [Genetics. 1974]
Genetic variation in a heterogeneous environment. I. Temporal heterogeneity and the absolute dominance model.
Hedrick PW. Genetics. 1974 Oct; 78(2):757-70.
Review Time required for gene frequency change in a deterministic model of gene-culture coevolution, with special reference to the lactose absorption problem. [Theor Popul Biol. 1991]
Review Time required for gene frequency change in a deterministic model of gene-culture coevolution, with special reference to the lactose absorption problem.
Aoki K. Theor Popul Biol. 1991 Dec; 40(3):354-68.
Review Adaptation or biased gene conversion? Extending the null hypothesis of molecular evolution. [Trends Genet. 2007]
Review Adaptation or biased gene conversion? Extending the null hypothesis of molecular evolution.
Galtier N, Duret L. Trends Genet. 2007 Jun; 23(6):273-7. Epub 2007 Apr 5.

See reviews... See all...

Cited by 16 PubMed Central articles

Review Population genetic inference from genomic sequence variation. [Genome Res. 2010]
Review Population genetic inference from genomic sequence variation.
Pool JE, Hellmann I, Jensen JD, Nielsen R. Genome Res. 2010 Mar; 20(3):291-300. Epub 2010 Jan 12.
Evolutionary selection between alternative modes of gene regulation. [Proc Natl Acad Sci U S A. 2009]
Evolutionary selection between alternative modes of gene regulation.
Gerland U, Hwa T. Proc Natl Acad Sci U S A. 2009 Jun 2; 106(22):8841-6. Epub 2009 May 22.
A stochastic version of the Price equation reveals the interplay of deterministic and stochastic processes in evolution. [BMC Evol Biol. 2008]
A stochastic version of the Price equation reveals the interplay of deterministic and stochastic processes in evolution.
Rice SH. BMC Evol Biol. 2008 Sep 25; 8:262. Epub 2008 Sep 25.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effect of temporal fluctuation of selection coefficient on gene frequency in a p...
Effect of temporal fluctuation of selection coefficient on gene frequency in a population.
Proc Natl Acad Sci U S A. 1975 Nov ;72(11):4541-5.

PubMed
Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated me...
Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.
J Cell Biol. 1999 Dec 13 ;147(6):1195-204.

PubMed
Problems and proposals for recording gingivitis and plaque.
Problems and proposals for recording gingivitis and plaque.
Int Dent J. 1975 Dec ;25(4):229-35.

PubMed
Folic acid improves arterial endothelial function in adults with hyperhomocystin...
Folic acid improves arterial endothelial function in adults with hyperhomocystinemia.
J Am Coll Cardiol. 1999 Dec ;34(7):2002-6.

PubMed
Substrate specificity of 5'-methylthioadenosine phosphorylase from human prostat...
Substrate specificity of 5'-methylthioadenosine phosphorylase from human prostate.
Biochem J. 1978 Dec 1 ;175(3):1043-50.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: