Brain Res. 1999 Oct 9;844(1-2):192-5.

The expression of proinflammatory cytokine mRNA in the sciatic-tibial nerve of ischemia-reperfusion injury.

Mitsui Y, Okamoto K, Martin DP, Schmelzer JD, Low PA.

Source

Department of Neurology, Mayo Clinic, 811 Guggenheim Bldg., 200 First Street SW, Rochester, MN 55905, USA.

Abstract

We evaluated the proinflammatory cytokines, TNF-alpha and IL-1beta, mRNA expression in the rat sciatic and tibial nerves following ischemia-reperfusion (IR) injury, using competitive RT-PCR, to explore the role of cytokines in IR injury. The expressions of both TNF-alpha and IL-1beta mRNA were related to severity of ischemia and occurred with reperfusion rather than ischemia alone. TNF-alpha gene expression peaked at 24 h of reperfusion, while that of IL-1beta peaked at 12 h. These data support the notion that the proinflammatory cytokines TNF-alpha and IL-1beta are involved in the inflammatory response of IR injury to the peripheral nervous system and may be involved in the pathophysiology of ischemic fiber degeneration.

PMID:: 10536276; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Activation of genes for superoxide dismutase, interleukin-1beta, tumor necrosis factor-alpha, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury. [Scand J Gastroenterol. 2000]
Activation of genes for superoxide dismutase, interleukin-1beta, tumor necrosis factor-alpha, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury.
Konturek PC, Duda A, Brzozowski T, Konturek SJ, Kwiecien S, Drozdowicz D, Pajdo R, Meixner H, Hahn EG. Scand J Gastroenterol. 2000 May; 35(5):452-63.
The role of proinflammatory cytokines in lung ischemia-reperfusion injury. [J Thorac Cardiovasc Surg. 2003]
The role of proinflammatory cytokines in lung ischemia-reperfusion injury.
Krishnadasan B, Naidu BV, Byrne K, Fraga C, Verrier ED, Mulligan MS. J Thorac Cardiovasc Surg. 2003 Feb; 125(2):261-72.
The expression of proinflammatory cytokines in the rat muscle flap with ischemia-reperfusion injury. [Ann Plast Surg. 2005]
The expression of proinflammatory cytokines in the rat muscle flap with ischemia-reperfusion injury.
Zhang F, Hu EC, Gerzenshtein J, Lei MP, Lineaweaver WC. Ann Plast Surg. 2005 Mar; 54(3):313-7.
Review Tumor necrosis factor-α in liver ischemia/reperfusion injury. [J Invest Surg. 2011]
Review Tumor necrosis factor-α in liver ischemia/reperfusion injury.
Perry BC, Soltys D, Toledo AH, Toledo-Pereyra LH. J Invest Surg. 2011; 24(4):178-88.
Review The role of TNF in diverse pathologic processes. [Biotherapy. 1991]
Review The role of TNF in diverse pathologic processes.
Kunkel SL, Strieter RM, Chensue SW, Campbell DA, Remick DG. Biotherapy. 1991; 3(2):135-41.

See reviews... See all...

Cited by 3 PubMed Central articles

Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha. [J Neurol Sci. 2008]
Decreased peripheral nerve damage after ischemia-reperfusion injury in mice lacking TNF-alpha.
Wang Y, Kawamura N, Schmelzer JD, Schmeichel AM, Low PA. J Neurol Sci. 2008 Apr 15; 267(1-2):107-11. Epub 2007 Oct 29.
Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rats. [J Brachial Plex Peripher Nerve Inj. 2006]
Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rats.
Coban YK, Ciralik H, Kurutas EB. J Brachial Plex Peripher Nerve Inj. 2006 Sep 29; 1:2. Epub 2006 Sep 29.
The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. [Proc Natl Acad Sci U S A. 2005]
The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy.
Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12525-30. Epub 2005 Aug 22.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The expression of proinflammatory cytokine mRNA in the sciatic-tibial nerve of i...
The expression of proinflammatory cytokine mRNA in the sciatic-tibial nerve of ischemia-reperfusion injury.
Brain Res. 1999 Oct 9 ;844(1-2):192-5.

PubMed
Comparison between partial ulnar and intercostal nerve transfers for reconstruct...
Comparison between partial ulnar and intercostal nerve transfers for reconstructing elbow flexion in patients with upper brachial plexus injuries.
J Brachial Plex Peripher Nerve Inj. 2010 Jan 26 ;5(1):4.

PubMed
Fibrolipomatous hamartoma in the median nerve in the arm - an unusual location b...
Fibrolipomatous hamartoma in the median nerve in the arm - an unusual location but with MR imaging characteristics: a case report.
J Brachial Plex Peripher Nerve Inj. 2010 Jan 12 ;5:1.

PubMed
Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropat...
Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats.
J Brachial Plex Peripher Nerve Inj. 2010 Jan 25 ;5:3.

PubMed
International symposium on peripheral nerve repair and regeneration and 2nd club...
International symposium on peripheral nerve repair and regeneration and 2nd club Brunelli meeting.
J Brachial Plex Peripher Nerve Inj. 2010 Mar 9 ;5:5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

The expression of proinflammatory cytokine mRNA in the sciatic-tibial nerve of ischemia-reperfusion injury.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Libraries

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information