Mol Med Today. 1999 Oct;5(10):448-53.

Strategies for targeting therapeutic gene delivery.

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Molecular Medicine Program, Guggenheim 18, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA. peng.kah@mayo.edu

Abstract

A major goal for gene therapy is to obtain targeted vectors that transfer genes efficiently to specific cell types. In theory, this can be achieved by targeting entry of the vector or by building gene expression cassettes that restrict gene expression to certain cell types. This review summarizes recent strategies to alter vector tropism for targeted gene delivery.

PMID:: 10498913; [PubMed - indexed for MEDLINE]

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