Science. 1999 Sep 24;285(5436):2126-9.

Drosophila S6 kinase: a regulator of cell size.

Montagne J, Stewart MJ, Stocker H, Hafen E, Kozma SC, Thomas G.

Source

Friedrich Miescher Institute, Maulbeerstrasse 66, 4058 Basel, Switzerland.

Abstract

Cell proliferation requires cell growth; that is, cells only divide after they reach a critical size. However, the mechanisms by which cells grow and maintain their appropriate size have remained elusive. Drosophila deficient in the S6 kinase gene (dS6K) exhibited an extreme delay in development and a severe reduction in body size. These flies had smaller cells rather than fewer cells. The effect was cell-autonomous, displayed throughout larval development, and distinct from that of ribosomal protein mutants (Minutes). Thus, the dS6K gene product regulates cell size in a cell-autonomous manner without impinging on cell number.

Comment in

Science. 1999 Sep 24;285(5436):2082-3.

PMID:: 10497130; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. [Nat Cell Biol. 2002]
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
Radimerski T, Montagne J, Rintelen F, Stocker H, van der Kaay J, Downes CP, Hafen E, Thomas G. Nat Cell Biol. 2002 Mar; 4(3):251-5.
The effect of developmental stage on the sensitivity of cell and body size to hypoxia in Drosophila melanogaster. [J Exp Biol. 2011]
The effect of developmental stage on the sensitivity of cell and body size to hypoxia in Drosophila melanogaster.
Heinrich EC, Farzin M, Klok CJ, Harrison JF. J Exp Biol. 2011 May 1; 214(Pt 9):1419-27.
Regulation of cellular growth by the Drosophila target of rapamycin dTOR. [Genes Dev. 2000]
Regulation of cellular growth by the Drosophila target of rapamycin dTOR.
Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP. Genes Dev. 2000 Nov 1; 14(21):2712-24.
Review The S6 kinase signaling pathway in the control of development and growth. [Biol Res. 2002]
Review The S6 kinase signaling pathway in the control of development and growth.
Thomas G. Biol Res. 2002; 35(2):305-13.
Review Uncoupling growth from the cell cycle. [Bioessays. 1998]
Review Uncoupling growth from the cell cycle.
Johnston LA. Bioessays. 1998 Apr; 20(4):283-6.

See reviews... See all...

Cited by over 100 PubMed Central articles

Developmental stability: a major role for cyclin G in drosophila melanogaster. [PLoS Genet. 2011]
Developmental stability: a major role for cyclin G in drosophila melanogaster.
Debat V, Bloyer S, Faradji F, Gidaszewski N, Navarro N, Orozco-Terwengel P, Ribeiro V, Schlötterer C, Deutsch JS, Peronnet F. PLoS Genet. 2011 Oct; 7(10):e1002314. Epub 2011 Oct 6.
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. [BMC Biol. 2011]
Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo.
Parisi F, Riccardo S, Daniel M, Saqcena M, Kundu N, Pession A, Grifoni D, Stocker H, Tabak E, Bellosta P. BMC Biol. 2011 Sep 27; 9:65. Epub 2011 Sep 27.
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning. [PLoS Genet. 2011]
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, Skoulakis EM. PLoS Genet. 2011 Sep; 7(9):e1002281. Epub 2011 Sep 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioSystems
Pathways and biological systems (BioSystems) that cite the current articles. Citations are from the BioSystems source databases (KEGG and BioCyc).
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Drosophila S6 kinase: a regulator of cell size.
Drosophila S6 kinase: a regulator of cell size.
Science. 1999 Sep 24 ;285(5436):2126-9.

PubMed
Identification of host proteins required for HIV infection through a functional ...
Identification of host proteins required for HIV infection through a functional genomic screen.
Science. 2008 Feb 15 ;319(5865):921-6. Epub 2008 Jan 10 .

PubMed
TBP2 is a substitute for TBP in Xenopus oocyte transcription.
TBP2 is a substitute for TBP in Xenopus oocyte transcription.
BMC Biol. 2009 Aug 3 ;7:45.

PubMed
Schwann cell but not olfactory ensheathing glia transplants improve hindlimb loc...
Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord.
J Neurosci. 2002 Aug 1 ;22(15):6670-81.

PubMed
Astrocytes derived from glial-restricted precursors promote spinal cord repair.
Astrocytes derived from glial-restricted precursors promote spinal cord repair.
J Biol. 2006 ;5(3):7. Epub 2006 Apr 27 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Drosophila S6 kinase: a regulator of cell size.

Source

Abstract

Comment in

Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support

Publication Types

MeSH Terms

Substances

Secondary Source ID

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Libraries

Supplemental Content

Related citations

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information