Trans R Soc Trop Med Hyg. 1999 Jan-Feb;93(1):4-11.

Comparison of bednets impregnated with different pyrethroids for their impact on mosquitoes and on re-infection with malaria after clearance of pre-existing infections with chlorproguanil-dapsone.

Maxwell CA, Myamba J, Njunwa KJ, Greenwood BM, Curtis CF.

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London School of Hygiene and Tropical Medicine, UK.

Abstract

Comparisons of bednets treated either with alphacypermethrin or lambdacyhalothrin showed similar effectiveness by various entomological criteria. Lambdacyhalothrin was associated with significantly more reports of nasal irritation than alphacypermethrin. The 2 net treatments were equally effective in reducing incidence of new malaria infections and the treated nets were much more effective than untreated nets. These measurements were made after clearing existing infections with chlorproguanil-dapsone. This drug combination was more than 99% effective in clearing infections 1 week after treatment and a study of children taken to an altitude with no malaria transmission showed that there were very few recrudescences.

PMID:: 10492776; [PubMed - indexed for MEDLINE]

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Chemical compound information

chlorproguanil

MW: 288.17 g/mol

MF: C₁₁H₁₅Cl₂N₅

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Comparison of bednets impregnated with different pyrethroids for their impact on mosquitoes and on re-infection with malaria after clearance of pre-existing infections with chlorproguanil-dapsone.

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