Trends Genet. 1999 Sep;15(9):358-63.

RNA-triggered gene silencing.

Source

Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA. fire@mail1.ciwemb.edu

Abstract

Double-stranded RNA (dsRNA) has recently been shown to trigger sequence-specific gene silencing in a wide variety of organisms, including nematodes, plants, trypanosomes, fruit flies and planaria; meanwhile an as yet uncharacterized RNA trigger has been shown to induce DNA methylation in several different plant systems. In addition to providing a surprisingly effective set of tools to interfere selectively with gene function, these observations are spurring new inquiries to understand RNA-triggered genetic-control mechanisms and their biological roles.

PMID:: 10461204; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

RNA, Double-Stranded

Grant Support

GM37706/GM/NIGMS NIH HHS/United States

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