Science. 1999 Jul 9;285(5425):248-51.

HMG-1 as a late mediator of endotoxin lethality in mice.

Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ.

Source

Department of Emergency Medicine and Department of Surgery, North Shore University Hospital-New York University School of Medicine, Manhasset, NY 11030, USA. hwang@picower.edu

Abstract

Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical trials, possibly because these cytokines are early mediators in pathogenesis. Here a potential late mediator of lethality is identified and characterized in a mouse model. High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1. Mice showed increased serum levels of HMG-1 from 8 to 32 hours after endotoxin exposure. Delayed administration of antibodies to HMG-1 attenuated endotoxin lethality in mice, and administration of HMG-1 itself was lethal. Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target.

PMID:: 10398600; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Research Materials

Libraries

LinkOut Holdings

Supplemental Content

Related citations

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. [J Exp Med. 2000]
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes.
Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, Janson A, Kokkola R, Zhang M, Yang H, et al. J Exp Med. 2000 Aug 21; 192(4):565-70.
HMG-1 as a mediator of acute lung inflammation. [J Immunol. 2000]
HMG-1 as a mediator of acute lung inflammation.
Abraham E, Arcaroli J, Carmody A, Wang H, Tracey KJ. J Immunol. 2000 Sep 15; 165(6):2950-4.
Review HMG-1 rediscovered as a cytokine. [Shock. 2001]
Review HMG-1 rediscovered as a cytokine.
Yang H, Wang H, Tracey KJ. Shock. 2001 Apr; 15(4):247-53.
PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia. [Int Immunopharmacol. 2008]
PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia.
Tang Y, Lv B, Wang H, Xiao X, Zuo X. Int Immunopharmacol. 2008 Dec 10; 8(12):1646-51. Epub 2008 Aug 17.
Review High mobility group box 1 protein as a late-acting mediator of acute lung inflammation. [Int J Occup Med Environ Health. 2004]
Review High mobility group box 1 protein as a late-acting mediator of acute lung inflammation.
Lutz W, Stetkiewicz J. Int J Occup Med Environ Health. 2004; 17(2):245-54.

See reviews... See all...

Cited by over 100 PubMed Central articles

Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis. [BMC Infect Dis. 2012]
Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis.
Narvaez-Rivera RM, Rendon A, Salinas-Carmona MC, Rosas-Taraco AG. BMC Infect Dis. 2012 Jan 20; 12:15. Epub 2012 Jan 20.
Regulation of inflammation by short chain Fatty acids. [Nutrients. 2011]
Regulation of inflammation by short chain Fatty acids.
Vinolo MA, Rodrigues HG, Nachbar RT, Curi R. Nutrients. 2011 Oct; 3(10):858-76. Epub 2011 Oct 14.
Meningococcal Outer Membrane Protein NhhA Triggers Apoptosis in Macrophages. [PLoS One. 2012]
Meningococcal Outer Membrane Protein NhhA Triggers Apoptosis in Macrophages.
Sjölinder M, Altenbacher G, Hagner M, Sun W, Schedin-Weiss S, Sjölinder H. PLoS One. 2012; 7(1):e29586. Epub 2012 Jan 4.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

HMG-1 as a late mediator of endotoxin lethality in mice.
HMG-1 as a late mediator of endotoxin lethality in mice.
Science. 1999 Jul 9 ;285(5425):248-51.

PubMed
Exercise therapy for the management of osteoarthritis of the hip joint: a system...
Exercise therapy for the management of osteoarthritis of the hip joint: a systematic review.
Arthritis Res Ther. 2009 ;11(3):R98. Epub 2009 Jun 25 .

PubMed
Cytokine-mediated down-regulation of B cell activity in SLE: effects of interleu...
Cytokine-mediated down-regulation of B cell activity in SLE: effects of interleukin-2 and transforming growth factor-beta.
Lupus. 1999 ;8(2):95-102.

PubMed
Evaluation of the patient acceptable symptom state in a pooled analysis of two m...
Evaluation of the patient acceptable symptom state in a pooled analysis of two multicentre, randomised, double-blind, placebo-controlled studies evaluating lumiracoxib and celecoxib in patients with osteoarthritis.
Arthritis Res Ther. 2007 ;9(1):R11.

PubMed
The role of human T-lymphocyte-monocyte contact in inflammation and tissue destr...
The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction.
Arthritis Res. 2002 ;4 Suppl 3:S169-76. Epub 2002 May 9 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: