Prog Biophys Mol Biol. 1999;71(3-4):313-41.

The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication.

Smith CM, Radzio-Andzelm E, Madhusudan, Akamine P, Taylor SS.

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San Diego Supercomputer Center, University of California, La Jolla 92093-0505, USA. csmith@sdsc.edu

Abstract

The protein kinase catalytic core in essence comprises an extended network of interactions that link distal parts of the molecule to the active site where they facilitate phosphoryl transfer from ATP to protein substrate. This review defines key sequence and structural elements, describes what is currently known about the molecular interactions, and how they are involved in catalysis.

PMID:: 10354702; [PubMed - indexed for MEDLINE]

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