Science. 1978 Nov 10;202(4368):631-3.

Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone.

Belchetz PE, Plant TM, Nakai Y, Keogh EJ, Knobil E.

Abstract

In rhesus monkeys with hypothalamic lesions that abolish gonadotropic hormone release by the pituitary gland, the constant infusion of exogenous gonadotropin-releasing hormone (GnRH) fails to restore sustained gonadotropin secretion. In marked contrast, intermittent administration of the synthetic decapeptide once per hour, the physiological frequency of gonadotropin release in the monkeys, reestablishes pituitary gonadotropin secretion. This phenomenon is attributable to the pattern of GnRH delivery rather than to the amounts of this hormone to which the cells of the pituitary are exposed. Moreover, the initiation of continuous GnRH administration in animals with lesions and in which gonadotropin secretion is reestablished by intermittent GnRH replacement can result in a "desensitization" or "down regulation" of the processes responsible for gonadotropin release.

PMID:: 100883; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Estradiol as a gonadotropin releasing hormone in the rhesus monkey. [Endocrinology. 1981]
Estradiol as a gonadotropin releasing hormone in the rhesus monkey.
Wildt L, Hausler A, Hutchison JS, Marshall G, Knobil E. Endocrinology. 1981 May; 108(5):2011-3.
Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. [Endocrinology. 1981]
Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey.
Wildt L, Häusler A, Marshall G, Hutchison JS, Plant TM, Belchetz PE, Knobil E. Endocrinology. 1981 Aug; 109(2):376-85.
Effect of pulsatile gonadotropin-releasing hormone on the release of luteinizing hormone and follicle-stimulating hormone in vitro by anterior pituitaries from lactating and cycling rats. [Endocrinology. 1982]
Effect of pulsatile gonadotropin-releasing hormone on the release of luteinizing hormone and follicle-stimulating hormone in vitro by anterior pituitaries from lactating and cycling rats.
Smith MS. Endocrinology. 1982 Mar; 110(3):882-91.
Review Pituitary effects of steroid hormones on secretion of follicle-stimulating hormone and luteinizing hormone. [Domest Anim Endocrinol. 2002]
Review Pituitary effects of steroid hormones on secretion of follicle-stimulating hormone and luteinizing hormone.
Nett TM, Turzillo AM, Baratta M, Rispoli LA. Domest Anim Endocrinol. 2002 Jul; 23(1-2):33-42.
Review Gonadotropin-releasing hormone and its clinical applications. [Obstet Gynecol Annu. 1984]
Review Gonadotropin-releasing hormone and its clinical applications.
Loucopoulos A, Ferin M. Obstet Gynecol Annu. 1984; 13:275-88.

See reviews... See all...

Cited by 58 PubMed Central articles

Generation of immortal cell lines from the adult pituitary: role of cAMP on differentiation of SOX2-expressing progenitor cells to mature gonadotropes. [PLoS One. 2011]
Generation of immortal cell lines from the adult pituitary: role of cAMP on differentiation of SOX2-expressing progenitor cells to mature gonadotropes.
Kim GL, Wang X, Chalmers JA, Thompson DR, Dhillon SS, Koletar MM, Belsham DD. PLoS One. 2011; 6(11):e27799. Epub 2011 Nov 21.
Atrazine and breast cancer: a framework assessment of the toxicological and epidemiological evidence. [Toxicol Sci. 2011]
Atrazine and breast cancer: a framework assessment of the toxicological and epidemiological evidence.
Simpkins JW, Swenberg JA, Weiss N, Brusick D, Eldridge JC, Stevens JT, Handa RJ, Hovey RC, Plant TM, Pastoor TP, et al. Toxicol Sci. 2011 Oct; 123(2):441-59. Epub 2011 Jul 18.
Effects of GnRH agonist treatment on steroidogenesis and folliculogenesis in the ovary of cyclic mice. [J Ovarian Res. 2010]
Effects of GnRH agonist treatment on steroidogenesis and folliculogenesis in the ovary of cyclic mice.
Singh P, Krishna A. J Ovarian Res. 2010 Nov 18; 3:26. Epub 2010 Nov 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Hypophysial responses to continuous and intermittent delivery of hypopthalamic g...
Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone.
Science. 1978 Nov 10 ;202(4368):631-3.

PubMed
Dissociable deficits in the decision-making cognition of chronic amphetamine abu...
Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms.
Neuropsychopharmacology. 1999 Apr ;20(4):322-39.

PubMed
A modification of the formol-ether concentration technique for increased sensiti...
A modification of the formol-ether concentration technique for increased sensitivity in detecting Schistosoma mansoni eggs.
Am J Trop Med Hyg. 1976 Nov ;25(6):818-23.

PubMed
Mosquito avoidance and bed net use in the Greater Accra Region, Ghana.
Mosquito avoidance and bed net use in the Greater Accra Region, Ghana.
J Biosoc Sci. 1999 Jan ;31(1):79-92.

PubMed
Pursuing the perceptual rather than the retinal stimulus.
Pursuing the perceptual rather than the retinal stimulus.
Vision Res. 1976 ;16(12):1371-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 58 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information