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    Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3006-11.

    Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo.

    Trahey M, Weissman IL.

    Source

    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. traheym@selway.umt.edu

    Abstract

    Mouse cyclophilin C-associated protein (CyCAP) is a member of the scavenger-receptor cysteine-rich domain superfamily and is 69% identical to the human Mac-2 binding protein. Here, we show that CyCAP is a widely expressed secreted glycoprotein that modulates the host response to endotoxin. Gene-targeted CyCAP-deficient mice are more sensitive to the lethal effects of endotoxin. In response to endotoxin, CyCAP-deficient mice overproduced interleukin 12 and interferon-gamma systemically and tumor necrosis factor alpha locally; these are proinflammatory molecules that also promote T helper 1 responses. Furthermore, macrophages stimulated in vitro with endotoxin in serum deficient in CyCAP secreted more tumor necrosis factor alpha, supporting the proposal that CyCAP specifically down-modulates endotoxin signaling.

    PMID:
    10077627
    [PubMed - indexed for MEDLINE]
    PMCID: PMC15885
    Free PMC Article

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