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    EMBO J. 1999 Feb 15;18(4):1071-80.

    The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis.

    Guo W, Roth D, Walch-Solimena C, Novick P.

    Source

    Department of Cell Biology, Yale University School of Medicine, PO Box 208002, New Haven, CT 06520-8002, USA.

    Abstract

    Polarized secretion requires proper targeting of secretory vesicles to specific sites on the plasma membrane. Here we report that the exocyst complex plays a key role in vesicle targeting. Sec15p, an exocyst component, can associate with secretory vesicles and interact specifically with the rab GTPase, Sec4p, in its GTP-bound form. A chain of protein-protein interactions leads from Sec4p and Sec15p on the vesicle, through various subunits of the exocyst, to Sec3p, which marks the sites of exocytosis on the plasma membrane. Sec4p may control the assembly of the exocyst. The exocyst may therefore function as a rab effector system for targeted secretion.

    PMID:
    10022848
    [PubMed - indexed for MEDLINE]
    PMCID: PMC1171198
    Free PMC Article

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