Binding of CDK9 to TRAF2. [J Cell Biochem. 1998]

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1: J Cell Biochem. 1998 Dec 15;71(4):467-78. Links

Binding of CDK9 to TRAF2.

MacLachlan TK, Sang N, De Luca A, Puri PL, Levrero M, Giordano A.

Sbarro Institute for Cancer Research and Molecular Medicine, Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

CDK9 has been recently shown to have increased kinase activity in differentiated cells in culture and a differentiated tissue-specific expression in the developing mouse. In order to identify factors that contribute to CDK9's differentiation-specific function, we screened a mouse embryonic library in the yeast two-hybrid system and found a tumor necrosis factor signal transducer, TRAF2, to be an interacting protein. CDK9 interacts with a conserved domain in the TRAF-C region of TRAF2, a motif that is known to bind other kinases involved in TRAF-mediated signaling. Endogenous interaction between the two proteins appears to be specific to differentiated tissue. TRAF2-mediated signaling may incorporate additional kinases to signal cell survival in myotubes, a cell type that is severely affected in TRAF2 knockout mice.

PMID: 9827693 [PubMed - indexed for MEDLINE]

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