Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.
Song J,
Murakami H,
Yang ZQ,
Koga C,
Adati N,
Murata T,
Geltinger C,
Saito-Ohara F,
Ikeuchi T,
Matsumura M,
Itakura K,
Kanazawa I,
Sun K,
Yokoyama KK.
RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki, 305-0074, Japan.
KNSL4 (Kid; kinesin-like DNA-binding protein) is a member of the kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Myc-associated zinc finger protein (MAZ) participates in both the initiation and the termination of transcription of target genes. We isolated genomic DNA clones that encoded KNSL4 and MAZ from a human cosmid library. Sequence analysis revealed that the two genes were very close to one another. The distance between the two genes was only 1. 2 kb, and this intervening 1.2-kb region was extremely GC-rich. The gene for KNSL4 spanned 16 kb and consisted of 14 exons and 13 introns, while the gene for MAZ spanned 6 kb and consisted of 5 exons and 4 introns. The two genes were mapped to chromosome 16p11.2 by fluorescence in situ hybridization. Copyright 1998 Academic Press.
PMID: 9790757 [PubMed - indexed for MEDLINE]