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Molecular characterization of NOS in a mollusc: expression in a giant modulatory neuron.
Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Brighton, UK.
Here we report on the molecular characterization of the first molluscan NOS in the CNS of the pond snail Lymnaea stagnalis. This Lymnaea NOS (Lym-nNOS) which is expressed preferentially in the CNS is most similar to mammalian neuronal NOS but contains tandem repeats of a seven amino acid motif not found in any other known NOS. We have localized Lym-nNOS to the serotonergic cerebral giant cells (CGCs) which modulate synaptic transmission within a neural network that generates feeding behavior. Our results suggest that the CGCs employ both NO and serotonin in the modulation of the central neural network underlying feeding.
PMID: 9552167 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Nitric oxide production by Biomphalaria glabrata haemocytes: effects of Schistosoma mansoni ESPs and regulation through the extracellular signal-regulated kinase pathway.
Zahoor Z, Davies AJ, Kirk RS, Rollinson D, Walker AJ.
Parasit Vectors. 2009 Apr 22; 2(1):18. Epub 2009 Apr 22.
[Parasit Vectors. 2009]
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ReviewBalancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide.
Derakhshan B, Hao G, Gross SS.
Cardiovasc Res. 2007 Jul 15; 75(2):210-9. Epub 2007 May 3.
[Cardiovasc Res. 2007]
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Nitric oxide synthase is induced in sporulation of Physarum polycephalum.
Golderer G, Werner ER, Leitner S, Gröbner P, Werner-Felmayer G.
Genes Dev. 2001 May 15; 15(10):1299-309.
[Genes Dev. 2001]