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1: J Virol. 1998 Mar;72(3):2010-21.Click here to read Click here to read Links

The genome sequence of herpes simplex virus type 2.

Dolan A, Jamieson FE, Cunningham C, Barnett BC, McGeoch DJ.

MRC Virology Unit, Institute of Virology, Glasgow, United Kingdom. a.dolan@vir.gla.ac.uk

The genomic DNA sequence of herpes simplex virus type 2 (HSV-2) strain HG52 was determined as 154,746 bp with a G+C content of 70.4%. A total of 74 genes encoding distinct proteins was identified; three of these were each present in two copies, within major repeat elements of the genome. The HSV-2 gene set corresponds closely with that of HSV-1, and the HSV-2 sequence prompted several local revisions to the published HSV-1 sequence (D. J. McGeoch, M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor, J. Gen. Virol. 69:1531-1574, 1988). No compelling evidence for the existence of any additional protein-coding genes in HSV-2 was identified.

PMID: 9499055 [PubMed - indexed for MEDLINE]

PMCID: PMC109494