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1: FEBS Lett. 1997 Dec 22;420(1):25-7.Click here to read Links

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.

Honda R, Tanaka H, Yasuda H.

School of Life Science, Tokyo University of Pharmacy and Life Science, Japan.

The tumor suppressor p53 is degraded by the ubiquitin-proteasome system. p53 was polyubiquitinated in the presence of E1, UbcH5 as E2 and MDM2 oncoprotein. A ubiquitin molecule bound MDM2 through sulfhydroxy bond which is characteristic of ubiquitin ligase (E3)-ubiquitin binding. The cysteine residue in the carboxyl terminus of MDM2 was essential for the activity. These data suggest that the MDM2 protein, which is induced by p53, functions as a ubiquitin ligase, E3, in human papillomavirus-uninfected cells which do not have E6 protein.

PMID: 9450543 [PubMed - indexed for MEDLINE]