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Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.
Franz Volhard Clinic, Humboldt University of Berlin, Germany.
The import of many proteins into the nucleus is mediated by the importin-alpha/beta heterodimer. While only one importin-beta gene has been found, several forms of importin-alpha have been described. In addition to the three human importin-alphas already identified, we report here the primary structure of two new human importin-alpha proteins. The five known human importin-alpha subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-alpha subfamilies are expressed in a variety of human tissues and mammalian cell lines.
PMID: 9395085 [PubMed - indexed for MEDLINE]
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Cited by 28 PubMed Central articles
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Regulation of Nuclear Import During Differentiation; The IMP alpha Gene Family and Spermatogenesis.
Holt JE, Ly-Huynh JD, Efthymiadis A, Hime GR, Loveland KL, Jans DA.
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[Curr Genomics. 2007]
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Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis.
Ratan R, Mason DA, Sinnot B, Goldfarb DS, Fleming RJ.
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[Genetics. 2008]
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Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2.
Theodore M, Kawai Y, Yang J, Kleshchenko Y, Reddy SP, Villalta F, Arinze IJ.
J Biol Chem. 2008 Apr 4; 283(14):8984-94. Epub 2008 Jan 31.
[J Biol Chem. 2008]
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