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Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase.
Department of Environmental Health, University of Washington, Seattle, USA.
Reverse transcription-polymerase chain reaction (RT-PCR) was used for the enzymatic synthesis of cDNA sequences encompassing the open reading frame for the catalytic subunit of mouse kidney glutamate-cysteine ligase (Glclc). Comparison of the mouse Glclc cDNA sequence and predicted protein sequence with that of rat Glclc and human GLCLC revealed between 94.8% and 88.4% cDNA homology and 98.4% to 95% amino acid identity, respectively.
PMID: 9224945 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death.
Franklin CC, Krejsa CM, Pierce RH, White CC, Fausto N, Kavanagh TJ.
Am J Pathol. 2002 May; 160(5):1887-94.
[Am J Pathol. 2002]
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Glutathione synthesis is essential for mouse development but not for cell growth in culture.
Shi ZZ, Osei-Frimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, Lieberman MW.
Proc Natl Acad Sci U S A. 2000 May 9; 97(10):5101-6.
[Proc Natl Acad Sci U S A. 2000]