Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Steck PA,
Pershouse MA,
Jasser SA,
Yung WK,
Lin H,
Ligon AH,
Langford LA,
Baumgard ML,
Hattier T,
Davis T,
Frye C,
Hu R,
Swedlund B,
Teng DH,
Tavtigian SV.
Department of Neuro-Oncology, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA. steckpa@audumla.mdacc.tmc.edu
Deletions involving regions of chromosome 10 occur in the vast majority (> 90%) of human glioblastoma multiformes. A region at chromosome 10q23-24 was implicated to contain a tumour suppressor gene and the identification of homozygous deletions in four glioma cell lines further refined the location. We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA. The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin. MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens. Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
PMID: 9090379 [PubMed - indexed for MEDLINE]