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Nature. 1997 Feb 13;385(6617):582-3, 585.
Crystal structure of the Src family tyrosine kinase Hck.
Laboratories of Molecular Biophysics, The Rockefeller University, New York 10021, USA.
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
PMID: 9024658 [PubMed - indexed for MEDLINE]
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Structures reported by this article