Monooxygenase-like sequence of a Rhodococcus equi ...[Antimicrob Agents Chemother. 1997]

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1: Antimicrob Agents Chemother. 1997 Jan;41(1):218-21. Links

Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.

Andersen SJ, Quan S, Gowan B, Dabbs ER.

Genetics Department, University of the Witwatersrand, Johannesburg, South Africa.

A DNA clone from Rhodococcus equi conferring low-level rifampin resistance through the ability to inactivate this antibiotic via its decomposition was identified. The iri (inactivation of rifampin) gene consisted of an open reading frame of 1,437 bp encoding a 479-amino-acid sequence strongly resembling those of monooxygenases acting upon phenolic compounds or involved in polyketide antibiotic synthesis. When expressed in Escherichia coli, the gene conferred resistance to a > 50-micrograms/ml concentration of the drug.

PMID: 8980786 [PubMed - indexed for MEDLINE]

PMCID: PMC163691

Light inhibits rifampicin inactivation and reduces rifampicin resistance due to a cloned mycobacterial ADP-ribosylation gene.
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[FEMS Microbiol Lett. 2000]
Characterization of mutations in the rpoB gene associated with rifampin resistance in Rhodococcus equi isolated from foals.
J Clin Microbiol. 2001 Aug; 39(8):2784-7.

[J Clin Microbiol. 2001]
Sequencing of the rpoB gene in Legionella pneumophila and characterization of mutations associated with rifampin resistance in the Legionellaceae.
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[Antimicrob Agents Chemother. 2000]
ReviewCloning of genes that have environmental and clinical importance from rhodococci and related bacteria.
Antonie Van Leeuwenhoek. 1998 Jul-Oct; 74(1-3):155-67.

[Antonie Van Leeuwenhoek. 1998]
Review[Current concepts and implications for future research on Rhodococcus equi]
Nippon Saikingaku Zasshi. 1996 Feb; 51(2):485-96.

[Nippon Saikingaku Zasshi. 1996]
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Contribution of rpoB2 RNA polymerase beta subunit gene to rifampin resistance in Nocardia species.
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The cell wall of the pathogenic bacterium Rhodococcus equi contains two channel-forming proteins with different properties.
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Rifampin (Rifadin® , Rimactane® , Rifamate® as a combination product containing Rifampin and Isoniazid, ...)
Rifampin eliminates bacteria that cause tuberculosis (TB). It is generally used with other drugs to treat tuberculosis or to eliminate Neisseria meningitidis (a bacteria) and to prevent you from giving these infections t...
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Cited by 9 PubMed Central articles

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