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Molecular cloning and expression of a novel peptide (LN1) gene: reduced expression in the renal cortex of lupus nephritis in MRL/lpr mouse.
First Department of Internal Medicine, Nara Medical University, Japan.
A gene has been identified by mRNA differential display whose expression is reduced in the renal cortex of MRL/lpr mouse. The nucleotide sequence of the cDNA contains an open reading frame that encodes a protein of 338 amino acids (termed LN1). In situ hybridization showed that LN1 mRNA is present in glomeruli, and a 39 kDa protein was detected in the kidney by immunoblot. A human LN1 cDNA was also isolated, the deduced amino acid sequence of which is 78% identical to that of mouse LN1. Although the function of LN1 remains to be elucidated, its reduced expression may contribute to the pathogenesis of lupus nephritis.
PMID: 8954131 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Fum3p, a 2-ketoglutarate-dependent dioxygenase required for C-5 hydroxylation of fumonisins in Fusarium verticillioides.
Ding Y, Bojja RS, Du L.
Appl Environ Microbiol. 2004 Apr; 70(4):1931-4.
[Appl Environ Microbiol. 2004]
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Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein.
Chambraud B, Radanyi C, Camonis JH, Rajkowski K, Schumacher M, Baulieu EE.
Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):2104-9.
[Proc Natl Acad Sci U S A. 1999]