Crystal structure of human estrogenic 17 beta-hydr...[Nat Struct Biol. 1996] - PubMed Result

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Nat Struct Biol. 1996 Aug;3(8):665-8.Links

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.

Azzi A, Rehse PH, Zhu DW, Campbell RL, Labrie F, Lin SX.

PMID: 8756321 [PubMed - indexed for MEDLINE]

Related articles

The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
Structure. 1996 Aug 15; 4(8):905-15.

[Structure. 1996]
Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD).
J Mol Biol. 2000 Oct 20; 303(2):311-27.

[J Mol Biol. 2000]
Structure and function of steroid dehydrogenases involved in hypertension, fertility, and cancer.
Steroids. 1997 Jan; 62(1):95-100.

[Steroids. 1997]
ReviewStructure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.
J Steroid Biochem Mol Biol. 2003 Jun; 85(2-5):247-55.

[J Steroid Biochem Mol Biol. 2003]
ReviewInhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Curr Med Chem. 2008; 15(2):137-50.

[Curr Med Chem. 2008]
» See reviews... | » See all...

Cited by 3 PubMed Central articles

Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction.
Gangloff A, Garneau A, Huang YW, Yang F, Lin SX. Biochem J. 2001 May 15; 356(Pt 1):269-76.

[Biochem J. 2001]
Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.
Sawicki MW, Erman M, Puranen T, Vihko P, Ghosh D. Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):840-5.

[Proc Natl Acad Sci U S A. 1999]
A novel 17beta-hydroxysteroid dehydrogenase in the fungus Cochliobolus lunatus: new insights into the evolution of steroid-hormone signalling.
Lanisnik Rizner T, Moeller G, Thole HH, Zakelj-Mavric M, Adamski J. Biochem J. 1999 Feb 1; 337 ( Pt 3):425-31.

[Biochem J. 1999]

Structures reported by this article

Estrogenic 17-Beta Hydroxysteroid Dehydrogenase Complexed 17-Beta-Estradiol

PDB: 1IOL

Source: Homo sapiens

Method: X-Ray Diffraction | Resolution: 2.3 Å

Patient Drug Information

Estrogen (Cenestin® , Enjuvia® , Estrace® , ...)
Estrogen is used to treat hot flushes ('hot flashes'; sudden strong feelings of heat and sweating) in women who are experiencing menopause ('change of life', the end of monthly menstrual periods). Some brands of estrogen...
Source: AHFS Consumer Medication Information

Recent Activity

Clear Turn Off Turn On

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with ...Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show