Characterization of a cDNA encoding murine coagula...[Thromb Haemost. 1996]

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1: Thromb Haemost. 1996 Mar;75(3):481-7.Links

Characterization of a cDNA encoding murine coagulation factor VII.

Idusogie E, Rosen E, Geng JP, Carmeliet P, Collen D, Castellino FJ.

Department of Chemistry and Biochemistry, University of Notre Dame, Indiana 46556, USA.

The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a lambda Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and a 3' poly(A) tail. The translation product is composed of a 41-amino acid signal/propeptide region followed by a 405-residue mature protein. The latter is highly homologous to that of human, rabbit, bovine, Rhesus monkey, and canine fVII. All protein domains of hfVII are strictly conserved in mfVII.

PMID: 8701412 [PubMed - indexed for MEDLINE]

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Cited by 4 PubMed Central articles

Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.
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Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII.
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Cited by 4 PubMed Central articles

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